He swept through the opening set in just 16 minutes, dropping just five points, before backing down a gear to conserve petrol for what he expects to be a more arduous second week of the championships.
The 32-year-old was made to work just hard enough by the Czech, who is clearly more unsafe than his 93rd ranking suggests but he never looked in any danger of not booking a last eight spot - which he did for the first time since 2011. "The only different thing", he said, "is that it's Federer in front of me". I knew he was much better than what he showed in that first set.
His mastery was only the beginning of things for those who spent 120 pounds (about $160) to be at Center Court and were afforded the rare treat of watching three of the greatest to ever lift a tennis racket.
Nadal, like Federer yet to drop a set, routed world number 93 Vesely on the eve of the Czech player's 25th birthday.
Was Mannarino intimidated by playing in that hallowed arena?
Bizarrely, organisers made a decision to put a mixed doubles match on Centre Court, which was concluded under the roof after sunset.
The eighth-seeded Anderson will meet defending champion Federer in the next round.
"I'm equally happy if I would have won all the matches in four sets".
IHOP acknowledges it faked IHOb name change
International House of Pancakes flipped the "P" in their name to a "b"; Jeff Flock explains what the "b" in IHOb stands for. The restaurant group also updated its website to remove the temporary IHOb logo and replace it with the usual IHOP version.
(12) Jelena Ostapenko bt. No. 20 Kiki Bertens.
Federer, 36, won 6-0 7-5 6-4 against the 22nd seed on Centre Court, and has now won 32 consecutive sets at SW19. The players are going to look up in the crowd and not understand what's going on at Wimbledon. "I guess there are other factors that play in".
"I always had that lead in the bag and then it was important for me to stay focused".
The resurgent Novak Djokovic, who reached the Queen's Club final last month, knocked out British No 1 Kyle Edmund to underline his grass-court credentials.
An eight-time victor of the men's singles at the All England Club, Federer was an overwhelming favorite against the 22nd seed and never looked like falling victim to a huge upset.
Three times he was scheduled last on court, putting him at risk of falling victim to fading light with the burden of having to return the following day.
The All England Club has come under increasing pressure to rethink its 2pm (1300GMT) start time for Sunday's men's singles final with the football showpiece in Moscow kicking off at 4pm in the United Kingdom (1500GMT).