Portia then told the audience that she chose to quit acting because she's started a new business.
First, de Rossi spoke about her and DeGeneres's upcoming trip to Africa as well as why she chose to quit acting.
Of course, he chose to write her character into a few episodes anyway, so the fifth season of Arrested Development, in which she plays Lindsay Bluth, will be her last acting job.
"She's just so awesome!"
Portia responded to this saying, "I was approaching 45 and I was just wondering was there something that I could tackle now that I've never done before that would be very challenging and different".
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"Once a Bluth, always a Bluth."
Following the premiere of the comedy's new season on May 29, Portia will instead focus growing her business, General Public, an art curation and publishing company that uses 3-D printing.
De Rossi, who has been married to DeGeneres since 2008, said the secret to their union is that they are best friends. "The painter spends so much time on one piece and then they sell it to one person so this kind of enables them to make more sales". She left Australia at the age of 21 to pursue a career in acting, snapping up roles in films such as Scream 2 and Stigmata.
"I just think it's awesome, too, because all you've ever known your entire life is acting, that's all you've known, and you took a chance, and you decided 'I'm gonna try a whole new thing that I've never done'". "Rather than the traditional flat print that kind of looks like a poster, we print with all the texture and articulation that's in the original painting", she explained.