The 37-year-old from Leigh, who played for Aston Villa and Bolton Wanderers in the Premier League and represented the Trinidad and Tobago worldwide team, was driving a Range Rover that was involved in a collision with a van on West Lane at about 7.55am on Tuesday.
Ashley Young, the Manchester United and England player, wrote: "Absolutely gutted to hear the news of the passing of Jlloyd Samuel".
Samuel played for Aston Villa and Bolton Wanderers in the top-flight and represented England at Under-21 level.
In a statement issued on Wednesday via Cheshire Police, the father-of-four's family said: "Jlloyd was a loving son, father, husband and brother".
The ex-Aston Villa, Bolton and Cardiff defender was involved in the smash moments after dropping his children off at school at around 8am yesterday.
Samuel was born in the city of San Fernando in the south-west of Trinidad but moved to England as a youngster.
After raising $110M, Circle raises announces new U.S. dollar-linked cryptocurrency
The investment round also included other notable names like Accel and Blockchain Capital . With business apparently humming, the company is making more moves.
"Such a good guy on and off the pitch and a truly good friend".
Villa later confirmed their players will wear black armbands in Tuesday's Championship play-off semi-final second leg with Middlesbrough as a mark of respect for Samuel.
"Rest in peace, Jlloyd. Our thoughts are with his family, friends and all who knew him".
Bolton Wanderers also paid tribute to their former man.
Villa posted on their official Twitter account: "We are deeply saddened to hear of the death of our former player Jlloyd Samuel at the age of just 37 in a vehicle accident".