Roma were similarly impressive at the Stadio Olimpico earlier in the competition, keeping clean sheets in each of their group games, and they will hope that helps them turn the tie around on March 13. Fred's well-taken free-kick proved to be the victor for the home side.
Whilst league football in the Ukraine may not be the highest standard, the Argentine striker has also shown real quality in the Champions League.
Here are some of the best Opta numbers ahead of two more crunch clashes. De Gea became the first visiting goalkeeper to keep Sevilla from scoring in a Champions League match at Sanchez-Pizjuan. But if Eusebio Di Francesco has done anything at Roma, it's been to instill a culture of always rising to the occasion - and the Champions League knockout rounds are one heck of an occasion to rise to.
In addition to the admiration from Manchester, Fred has also impressed Brazil coach Tite, who included him in the 23-man squad for World Cup qualifiers against Bolivia and Chile in October a year ago.
"We dropped badly after their [first] goal, but not just physically, above all psychologically", Di Francesco told Mediaset Premium.
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"I am not at all satisfied with the second half".
Shakhtar have already come through a tough group which featured Manchester City, Napoli and Feyenoord, and will now be looking to follow that up with a strong showing tonight.
Veteran midfielder Simone Perrotta was able to put Roma into a first-half lead with a deflected header at the back post.
Shakhtar took control and Alisson made superb saves from Marlos and Taison before he was beaten by a brilliant free kick from fellow Brazilian Fred, who sent a looping shot over the wall and in off the crossbar.
Shakhtar thought they had made it three in injury time but a combination of Alisson and defender Bruno Peres on the line somehow kept out Ferreyra's shot.