Now, for the first time since, Williams is opening up about her birth experience - and the complications that followed.
Serena Williams played an exhibition match in Abu Dhabi in late December but pulled out of this month's Australian Open.
Her next grand slam victory will be her 24th, equalling Margaret Court for the most of all-time in women's tennis while the 36-year-old will have to wait until 2019 to try and usurp Thelma Coyne Long as the oldest victor of the Australian Open (35 years and eight months in 1954).
After her heart rate severely dropped during contractions, Ms. Williams gave birth to her daughter on September 1, 2017, via emergency cesarean section.
The Serena Williams pregnancy story is already wonderful - but if the 23-time grand slam winner's 2018 plays out as hoped, the story is going to be completely remarkable.
"Maybe this goes without saying, but it needs to be said in a powerful way: I absolutely want more Grand Slams", she said. I'm well aware of the record books, unfortunately.
"It's not a secret that I have my sights on 25", said the 36-year-old Williams. "I told you, I need a CT scan and a heparin drip", Williams said she told the medical team. "I say this without a lot of conviction, but I feel like Halep had such a disappointing 2017 in the Majors, and I feel she is determined to turn that around", Evert informed.
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Several small blood clots were found in her lungs, and Williams was put on an anticoagulant. "That's a different feeling for me".
The 26-year-old Romanian is full of confidence after lifting the title at Shenzhen in dominant fashion, but will need to overcome her sorry record at Melbourne Park where she has lost in the first round in both of the past two years when seeded in the top four. "I was happy to change diapers", Ohanian, who married Williams in November, told Vogue, adding that the hardest part was "not being able to help".
The sports star has a history of blood clots, so she was the one who raised the alarm after she found herself feeling short of breath 24 hours after becoming a mum. But Serena insisted, and soon enough a doctor was performing an ultrasound of her legs. Furthermore, Serena's fresh C-section wound had popped open from her coughing fits caused by the pulmonary embolism, and when she returned to surgery, doctors discovered a large hematoma had flooded her abdomen - caused by the lifesaving blood-thinning medication she was taking for her blood clots.
In his new post on Thursday, Ohanian, who tied the knot with Williams in November, wrote next to a picture of his wife and child, "I can't imagine life without these two".
Following her surgeries, she was forced to spend her first six weeks of motherhood unable to get out of bed. The factors which cause this alarming gap include differences in socioeconomic status, access to health care, education and insurance coverage. "I'm not asking you to like it", she explained in a frank conversation about body critics.
She said: "That was an incredible feeling (being handed her daughter)".